Novel Insights into the Cardioprotective Effects of Calcitriol in Myocardial Infarction.

ABSTRACT:

Background

Increasing evidence indicates that vitamin D deficiency negatively affects the cardiovascular system. Here we studied the therapeutic effects of calcitriol in myocardial infarction (MI) and investigated its underlying mechanisms.

Methods

A MI model of Kun-ming mice induced by left anterior descending coronary artery ligation was utilized to study the potential therapeutic effects of calcitriol on MI. AC16 human cardiomyocyte-like cells treated with TNF-α were used for exploring the mechanisms that underlie the cardioprotective effects of calcitriol.

Results

We observed that calcitriol reversed adverse cardiovascular function and cardiac remodeling in post-MI mice. Mechanistically, calcitriol suppressed MI-induced cardiac inflammation, ameliorated cardiomyoc

SUBMITTER: Yang S 

PROVIDER: S-EPMC9139780 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature