Booster COVID-19 Vaccines for Immune-Mediated Inflammatory Disease Patients: A Systematic Review and Meta-Analysis of Efficacy and Safety.

ABSTRACT:

Background

Seroconversion and longevity of vaccine-induced immune response is blunted in immune-mediated inflammatory disease (IMID) patients owing to immunosuppressive regimens. COVID-19 booster vaccines after a primary series have been proposed with inconclusive evidence on efficacy to date.

Methods

This PROSPERO-registered systematic review (CRD42022302534) was conducted according to PRISMA guidelines. PubMed, EMBASE, CENTRAL, Web of Science, CORD-19, WHO ICTRP, and medRxiv were searched up to 28 February 2022 for eligible studies. Risk of bias was assessed using the Joanna Briggs Institute critical appraisal tools.

Results

From 6647 records, 17 prospective studies were included for systematic review and 12 in meta-analysis of primary series non-responders. The ris

SUBMITTER: Lee ARYB 

PROVIDER: S-EPMC9144569 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature