Association between Body Mass Index and Renal Outcomes Modified by Chronic Kidney Disease and Anemia: The Obesity Paradox for Renal Outcomes.

ABSTRACT: Obesity-related nephropathy is associated with renal function progression. However, some studies have associated a high body mass index (BMI) with improved renal outcomes-this is referred to as the obesity paradox for renal outcomes, especially in relation to advanced chronic kidney disease (CKD). Central obesity can explain the obesity paradox in all-cause mortality. However, whether obesity or central obesity is associated with renal outcomes (renal replacement therapy or a 50% decline in the estimated glomerular filtration rate) in patients with advanced CKD remains unclear. Our study included 3605 Asian patients with CKD stages 1-5 divided into six groups according to their BMI (between 15 and 35 kg/m²). Through linear regression, BMI was positively associated with hemoglobi

SUBMITTER: Hung CC 

PROVIDER: S-EPMC9144670 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature