Indirect SPECT Imaging Evaluation for Possible Nose-to-Brain Drug Delivery Using a Compound with Poor Blood-Brain Barrier Permeability in Mice.

ABSTRACT: Single-photon emission computed tomography (SPECT) imaging using intravenous radioactive ligand administration to indirectly evaluate the time-dependent effect of intranasal drugs with poor blood-brain barrier permeability on brain drug distributions in mice was evaluated. The biodistribution was examined using domperidone, a dopamine D2 receptor ligand, as the model drug, with intranasal administration at 0, 15, or 30 min before intravenous [¹²³I]IBZM administration. In the striatum, [¹²³I]IBZM accumulation was significantly lower after intranasal (IN) domperidone administration than in controls 15 min after intravenous [¹²⁵I]IBZM administration. [¹²³I]IBZM SPECT was acquired with intravenous (IV) or IN domperidone administration 15 min before [

SUBMITTER: Mizutani A 

PROVIDER: S-EPMC9145277 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature