Ontology highlight
ABSTRACT:
SUBMITTER: Bausart M
PROVIDER: S-EPMC9145362 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Bausart Mathilde M Vanvarenberg Kevin K Ucakar Bernard B Lopes Alessandra A Vandermeulen Gaëlle G Malfanti Alessio A Préat Véronique V
Pharmaceutics 20220510 5
Combination immunotherapy has emerged as a promising strategy to increase the immune response in glioblastoma (GBM) and overcome the complex immunosuppression occurring in its microenvironment. In this study, we hypothesized that combining DNA vaccines-to stimulate a specific immune response-and dual immune checkpoint blockade (ICB)-to decrease the immunosuppression exerted on T cells-will improve the immune response and the survival in an orthotopic unresectable GL261 model. We first highlighte ...[more]