Dataset Information

Effects of Exercise and Physical Activity Levels on Vaccination Efficacy: A Systematic Review and Meta-Analysis.

ABSTRACT:

Objective

We examined whether different intensities of exercise and/or physical activity (PA) levels affected and/or associated with vaccination efficacy.

Methods

A systematic review and meta-analysis was conducted and registered with PROSPERO (CRD42021230108). The PubMed, EMBASE, Cochrane Library (trials), SportDiscus, and CINAHL databases were searched up to January 2022.

Results

In total, 38 eligible studies were included. Chronic exercise increased influenza antibodies (standardized mean difference (SMD) = 0.49, confidence interval (CI) = 0.25-0.73, Z = 3.95, I² = 90%, p < 0.01), which was mainly driven by aerobic exercise (SMD = 0.39, CI = 0.19-0.58, Z = 3.96, I² = 77%, p < 0.01) as opposed to combined (aerobic + resistance; p = 0.07) or other exercise types (i.e., taiji and qigong, unspecified; p > 0.05). PA levels positively affected antibodies in response to influenza vaccination (SMD = 0.18, CI = 0.02-0.34, Z = 2.21, I² = 76%, p = 0.03), which was mainly driven by high PA levels compared to moderate PA levels (Chi² = 10.35, I² = 90.3%, p < 0.01). Physically active individuals developed influenza antibodies in response to vaccination in >4 weeks (SMD = 0.64, CI = 0.30-0.98, Z = 3.72, I² = 83%, p < 0.01) as opposed to <4 weeks (p > 0.05; Chi2 = 13.40, I² = 92.5%, p < 0.01) post vaccination.

Conclusion

Chronic aerobic exercise or high PA levels increased influenza antibodies in humans more than vaccinated individuals with no participation in exercise/PA. The evidence regarding the effects of exercise/PA levels on antibodies in response to vaccines other than influenza is extremely limited.

SUBMITTER: Dinas PC

PROVIDER: S-EPMC9146578 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Effects of Exercise and Physical Activity Levels on Vaccination Efficacy: A Systematic Review and Meta-Analysis.

Dinas Petros C PC Koutedakis Yiannis Y Ioannou Leonidas G LG Metsios George G Kitas George D GD

Vaccines 20220512 5

Objective: We examined whether different intensities of exercise and/or physical activity (PA) levels affected and/or associated with vaccination efficacy. Methods: A systematic review and meta-analysis was conducted and registered with PROSPERO (CRD42021230108). The PubMed, EMBASE, Cochrane Library (trials), SportDiscus, and CINAHL databases were searched up to January 2022. Results: In total, 38 eligible studies were included. Chronic exercise increased influenza antibodies (standardized mean ...[more]

PMID: 35632525

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Dataset Information

Effects of Exercise and Physical Activity Levels on Vaccination Efficacy: A Systematic Review and Meta-Analysis.

Objective

Methods

Results

Conclusion

Publications

Effects of Exercise and Physical Activity Levels on Vaccination Efficacy: A Systematic Review and Meta-Analysis.

Similar Datasets

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