Dose-Response Association of Metformin with Parkinson's Disease Odds in Type 2 Diabetes Mellitus.

ABSTRACT:

Background

Studies have demonstrated that patients with diabetes mellitus who receive metformin have a lower risk of developing Parkinson's disease (PD). However, studies have also suggested that metformin may increase the risk of PD. In this study, we investigated whether metformin use was associated with the risk of PD in type 2 diabetes mellitus (T2DM).

Methods

In this population-based cross-sectional study, patients with T2DM diagnosed between 2001 and 2018 were enrolled. We categorized these patients as metformin users or nonusers. Participants below 50 years old were excluded. Two models were employed to evaluate the associations of metformin exposure and use intensity with PD after 3 and 5 years of follow-up.

Results

Patients with T2DM who received <300 cumu

SUBMITTER: Huang KH 

PROVIDER: S-EPMC9147745 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature