Extended familial risk of suicide death is associated with younger age at death and elevated polygenic risk of suicide.

ABSTRACT: Suicide accounts for >800,000 deaths annually worldwide; prevention is an urgent public health issue. Identification of risk factors remains challenging due to complexity and heterogeneity. The study of suicide deaths with increased extended familial risk provides an avenue to reduce etiological heterogeneity and explore traits associated with increased genetic liability. Using extensive genealogical records, we identified high-risk families where distant relatedness of suicides implicates genetic risk. We compared phenotypic and polygenic risk score (PRS) data between suicides in high-risk extended families (high familial risk (HFR), n = 1,634), suicides linked to genealogical data not in any high-risk families (low familial risk (LFR), n = 147), and suicides not linked to genealogical da

SUBMITTER: Coon H 

PROVIDER: S-EPMC9149029 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature