Preventing unfolded protein response-induced ion channel dysregulation to treat arrhythmias.

ABSTRACT: Cardiomyopathies are associated with arrhythmias and cardiac ion channel downregulation. This downregulation is arrhythmogenic. Paradoxically, antiarrhythmic therapies are based on ion channel-blocking drugs that further downregulate these channels and exhibit proarrhythmic risk. Recent studies have shown that inhibition of the protein kinase RNA-like ER kinase (PERK) arm of the unfolded protein response (UPR) prevents select cardiac ion channel downregulation and plays a protective role against arrhythmias. Prevention of ion channel downregulation represents as a novel therapeutic strategy to treat arrhythmias in myocardial infarction and heart failure.

SUBMITTER: Liu M 

PROVIDER: S-EPMC9149111 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature