Associations between perceived discrimination and immune cell composition in the Jackson Heart Study.

ABSTRACT: African American adults suffer disproportionately from several non-communicable and infectious diseases. Among numerous contributing factors, perceived discrimination is considered a stressor for members of historically marginalized groups that contributes to health risk, although biological pathways are incompletely understood. Previous studies have reported associations between stress and both an up-regulation of non-specific (innate) inflammation and down-regulation of specific (adaptive) immunity. While associations between perceived discrimination and markers of inflammation have been explored, it is unclear if this is part of an overall shift that also includes down-regulated adaptive immunity. Relying on a large cross-section of African American adults (n = 3,319) from the Jackson H

SUBMITTER: Aronoff JE 

PROVIDER: S-EPMC9149129 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature