Association of urinary albumin:creatinine ratio with incident frailty in older populations.

ABSTRACT:

Background

The longitudinal relationship of albuminuria with incident frailty remains unknown. Therefore we aimed to evaluate the relation of albuminuria with the risk of incident frailty in older adults.

Methods

A total of 1115 participants ≥65 years of age (average age 80.3 years) who were free of frailty in the Chinese Longitudinal Healthy Longevity Survey were included. The outcome was incident frailty, defined as a frailty index ≥0.25 during follow-up. Cox proportional hazards models were used to assess the association of the urinary albumin:creatinine ratio (UACR) with frailty.

Results

During a median follow-up duration of 5.3 years, 295 (26.5%) participants developed incident frailty. Overall, the UACR was significantly positively associated with the risk of in

SUBMITTER: Liu M 

PROVIDER: S-EPMC9155239 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature