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Sperm selection with hyaluronic acid improved live birth outcomes among older couples and was connected to sperm DNA quality, potentially affecting all treatment outcomes.

ABSTRACT:

SUBMITTER: West R

PROVIDER: S-EPMC9156852 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Sperm selection with hyaluronic acid improved live birth outcomes among older couples and was connected to sperm DNA quality, potentially affecting all treatment outcomes.

West Robert R Coomarasamy Arri A Frew Lorraine L Hutton Rachel R Kirkman-Brown Jackson J Lawlor Martin M Lewis Sheena S Partanen Riitta R Payne-Dwyer Alex A Román-Montañana Claudia C Torabi Forough F Tsagdi Sofia S Miller David D

Human reproduction (Oxford, England) 20220501 6

<h4>Study question</h4>What effects did treatment using hyaluronic acid (HA) binding/selection prior to ICSI have on clinical outcomes in the Hyaluronic Acid Binding sperm Selection (HABSelect) clinical trial?<h4>Summary answer</h4>Older women randomized to the trial's experimental arm (selection of sperm bound to immobilized (solid-state) HA) had the same live birth rates as younger women, most likely a result of better avoidance of sperm with damaged DNA.<h4>What is known already</h4>Recent ra ...[more]

PMID: 35459947

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