Soluble factors secreted by human Wharton's jelly mesenchymal stromal/stem cells exhibit therapeutic radioprotection: A mechanistic study with integrating network biology.

ABSTRACT:

Background

Human Wharton's jelly-derived mesenchymal stromal/stem cells (hWJ-MSCs) have gained considerable attention in their applications in cell-based therapy due to several advantages offered by them. Recently, we reported that hWJ-MSCs and their conditioned medium have significant therapeutic radioprotective potential. This finding raised an obvious question to identify unique features of hWJ-MSCs over other sources of stem cells for a better understanding of its radioprotective mechanism.

Aim

To understand the radioprotective mechanism of soluble factors secreted by hWJ-MSCs and identification of their unique genes.

Methods

Propidium iodide staining, endogenous spleen colony-forming assay, and survival study were carried out for radioprotection studies. Homeosta

SUBMITTER: Maurya DK 

PROVIDER: S-EPMC9157603 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature