Metabolic reprograming of MDSCs within tumor microenvironment and targeting for cancer immunotherapy.

ABSTRACT: A number of emerging studies in field of immune metabolism have indicated that cellular metabolic reprograming serves as a major administrator in maintaining the viability and functions of both tumor cells and immune cells. As one of the most important immunosuppressive cells in tumor stroma, myeloid-derived suppressor cells (MDSCs) dynamically orchestrate their metabolic pathways in response to the complicated tumor microenvironment (TME), a process that consequently limits the therapeutic effectiveness of anti-cancer treatment modalities. In this context, the metabolic vulnerabilities of MDSCs could be exploited as a novel immune metabolic checkpoint upon which to intervene for promoting the efficacy of immunotherapy. Here, we have discussed about recent studies highlighting the importan

SUBMITTER: Li Q 

PROVIDER: S-EPMC9160034 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature