Antibiotic-resistant organisms establish reservoirs in new hospital built environments and are related to patient blood infection isolates.

ABSTRACT:

Background

Healthcare-associated infections due to antibiotic-resistant organisms pose an acute and rising threat to critically ill and immunocompromised patients. To evaluate reservoirs of antibiotic-resistant organisms as a source of transmission to patients, we interrogated isolates from environmental surfaces, patient feces, and patient blood infections from an established and a newly built intensive care unit.

Methods

We used selective culture to recover 829 antibiotic-resistant organisms from 1594 environmental and 72 patient fecal samples, in addition to 81 isolates from blood cultures. We conducted antibiotic susceptibility testing and short- and long-read whole genome sequencing on recovered isolates.

Results

Antibiotic-resistant organism burden is highest in

SUBMITTER: Sukhum KV 

PROVIDER: S-EPMC9160058 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature