Rethinking urinary antibiotic breakpoints: analysis of urinary antibiotic concentrations to treat multidrug resistant organisms.

ABSTRACT:

Objective

The present study analyzed whether renally eliminated antibiotics achieve sufficient urinary concentrations based on their pharmacokinetic/pharmacodynamic principles to effectively eradicate organisms deemed resistant by automated susceptibility testing.

Results

Lower median minimum inhibitory concentrations against enterobacteriaceae were noted for ceftriaxone, cefepime, and doripenem when comparing Etest^® to Vitek^®. All Pseudomonas aeruginosa isolates were susceptible to cefepime, ciprofloxacin, and doripenem with both susceptibility methods, but higher median minimum inhibitory concentrations were observed with Etest^®. Urine concentrations/time profiles were calculated for standard doses of ceftriaxone, cefepime, doripenem, and c

SUBMITTER: Chastain DB 

PROVIDER: S-EPMC6053836 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature