Targeting AKT and CK2 represents a novel therapeutic strategy for SMO constitutive activation-driven medulloblastoma.

ABSTRACT:

Aims

Sonic hedgehog subtype medulloblastoma is featured with overactivation of hedgehog pathway and can be targeted by SMO-specific inhibitors. However, the resistance is frequently developed leading to treatment failure of SMO inhibitors. W535L mutation of SMO (SMO^W535L ) is thought to be an oncogenic driver for Sonic hedgehog subtype MB and confer resistance to SMO inhibitors. The regulation network of SMO^W535L remains to be explored in comparison with wild-type SMO (SMO^WT ).

Methods

In this study, we profiled transcriptomes, methylomes, and interactomes of MB cells expression SMOWT or SMOW535L in the treatment of DMSO or SMO inhibitor, respectively.

Results

Analysis of transcriptomic data indicated that SMO inhibitor disrupted proce

SUBMITTER: Yao YL 

PROVIDER: S-EPMC9160449 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature