Prognostic significance of incidental suspected transthyretin amyloidosis on routine bone scintigraphy.

ABSTRACT:

Background

Transthyretin amyloidosis (ATTR) is an occasional incidental finding on bone scintigraphy. We studied its prognostic impact in elderly patients.

Methods

The study population consisted of 2000 patients aged over 70 years who underwent bone scintigraphies with clinical indications in three nuclear medicine departments (Kymenlaakso, Jorvi and Meilahti hospitals) in Finland. All studies were performed using ^99mTechnetium labeled hydroxymethylene diphosphonate (HMDP). ATTR was suspected in patients with ≥grade 2 Perugini grade uptake (grade 0-3). Heart-to-contralateral ratio (H/CL) of ≥ 1.30 was considered positive for ATTR. The overall and cardiovascular mortality were obtained from the Finnish National Statistical Service.

Results

There were a total

SUBMITTER: Suomalainen O 

PROVIDER: S-EPMC9163012 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature