Glioblastoma microenvironment contains multiple hormonal and non-hormonal growth-stimulating factors.

ABSTRACT:

Background

The growth of malignant tumors is influenced by their microenvironment. Glioblastoma, an aggressive primary brain tumor, may have cysts containing fluid that represents the tumor microenvironment. The aim of this study was to investigate whether the cyst fluid of cystic glioblastomas contains growth-stimulating factors. Identification of such growth factors may pave the way for the development of targeted anti-glioblastoma therapies.

Methods

We performed hormone analysis of cyst fluid from 25 cystic glioblastomas and proteomics analysis of cyst fluid from another 12 cystic glioblastomas.

Results

Glioblastoma cyst fluid contained hormones within wide concentration ranges: Insulin-like growth factor 1 (0-13.7 nmol/L), insulin (1.4-133 pmol/L), erythropoietin

SUBMITTER: Dahlberg D 

PROVIDER: S-EPMC9166426 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature