Survival of BRCA1/BRCA2-associated pT1 breast cancer patients, a cohort study.

ABSTRACT:

Purpose

Intensive screening in BRCA1/2 mutation carriers aims to improve breast cancer (BC) prognosis. Our aim is to clarify the prognostic impact of tumor size in BRCA mutation carriers with a pT1 BC, which is currently unclear. We are especially interested in differences between pT1a, pT1b, and pT1c regarding the prognosis of node-negative breast cancer, the effect of chemotherapy, and the prevalence of lymph node involvement.

Methods

For this study, BRCA1/2-associated BC patients were selected from a nationwide cohort. Primary outcomes were 10-year overall survival (OS) per pT1a-b-c group and the effect of chemotherapy on prognosis of node-negative BC, using Kaplan-Meier and Cox models. Finally, we evaluated lymph node involvement per pT1a-b-c group.

Results

963 wo

SUBMITTER: van Barele M 

PROVIDER: S-EPMC9167195 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature