Continuous monitoring with wearables in multiple sclerosis reveals an association of cardiac autonomic dysfunction with disease severity.

ABSTRACT:

Background

Dysfunction of the autonomic nervous system is common in multiple sclerosis patients, and probably present years before diagnosis, but its role in the disease is poorly understood.

Objectives

To study the autonomic nervous system in patients with multiple sclerosis using cardiac autonomic regulation measured with a wearable.

Methods

In a two-week study, we present a method to standardize the measurement of heart rate variability using a wearable sensor that allows the investigation of circadian trends. Using this method, we investigate the relationship of cardiac autonomic dysfunction with clinical hallmarks and subjective burden of fatigue and autonomic symptoms.

Results

In 55 patients with multiple sclerosis and 24 healthy age- and gender-matched c

SUBMITTER: Hilty M 

PROVIDER: S-EPMC9168869 | biostudies-literature | 2022 Apr-Jun

REPOSITORIES: biostudies-literature