Fetal alleles predisposing to metabolically favorable adiposity are associated with higher birth weight.

ABSTRACT:

Background

Higher birthweight is associated with higher adult body mass index (BMI). Alleles that predispose to greater adult adiposity might act in fetal life to increase fetal growth and birthweight. Whether there are fetal effects of recently identified adult metabolically favorable adiposity alleles on birthweight is unknown.

Aim

We aimed to test the effect on birthweight of fetal genetic predisposition to higher metabolically favorable adult adiposity and compare that with the effect of fetal genetic predisposition to higher adult BMI.

Methods

We used published genome wide association study data (n = upto 406 063) to estimate fetal effects on birthweight (adjusting for maternal genotype) of alleles known to raise metabolically favorable adult adiposity or BMI. We

SUBMITTER: Thompson WD 

PROVIDER: S-EPMC9169452 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature