The Role of Complement in Microangiopathic Lesions of IgA Nephropathy.

ABSTRACT:

Introduction

Arteriolar microangiopathic (MA) lesions are independent risk factors for IgA nephropathy (IgAN) patient prognosis, and the underlying mechanism remains to be elucidated. The complement plays an important role in IgAN and thrombotic microangiopathy; however, its role in MA lesions in IgAN remains unclear.

Methods

Immunohistochemistry was performed to detect arteriolar complement deposition. Enzyme-linked immunosorbent assay (ELISA) and whole-exome sequencing were performed to explore possible mechanism.

Results

In this study, we found that patients with IgAN with MA lesions have more complement deposition, especially C4d, on renal arterioles than those in patients with arteriolosclerosis (AS) and patients with no vascular lesions (100% vs. 53% vs.

SUBMITTER: Li J 

PROVIDER: S-EPMC9171706 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature