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BPDCN: When polychemotherapy does not compromise allogeneic CD123 CAR-T cell cytotoxicity.

ABSTRACT: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematological malignancy with poor prognosis and no treatment consensus. Combining chemotherapy and immunotherapy is a promising strategy to enhance therapeutic effect. Before combining these therapies, the influence of one on the other has to be explored. We set up a model to test the combination of polychemotherapy - named methotrexate, idarubicine, dexamethasone, and L-asparaginase (MIDA) - and CD123 CAR-T cell therapy. We showed that CD123 CAR-T cells exert the same effect on BPDCN models alone, or after MIDA regimen. These data support a preclinical rationale to use immunotherapy after a treatment with polychemotherapy for BPDCN patients.

SUBMITTER: Poussard M

PROVIDER: S-EPMC9176134 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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BPDCN: When polychemotherapy does not compromise allogeneic CD123 CAR-T cell cytotoxicity.

Poussard Margaux M Philippe Laure L Fredon Maxime M Bôle-Richard Elodie E Biichle Sabeha S Renosi Florian F Perrin Sophie S Kroemer Marie M Limat Samuel S Bonnefoy Francis F Daguindau Etienne E Deconinck Eric E Gruson Bérengère B Saas Philippe P Adotévi Olivier O Garnache-Ottou Francine F Angelot-Delettre Fanny F

EJHaem 20201213 1

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematological malignancy with poor prognosis and no treatment consensus. Combining chemotherapy and immunotherapy is a promising strategy to enhance therapeutic effect. Before combining these therapies, the influence of one on the other has to be explored. We set up a model to test the combination of polychemotherapy - named methotrexate, idarubicine, dexamethasone, and L-asparaginase (MIDA) - and CD123 CAR-T cell therapy. We showed ...[more]

PMID: 35846081

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