Ontology highlight
ABSTRACT:
SUBMITTER: Jang B
PROVIDER: S-EPMC9180903 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Jang Bohee B Kim Ayoung A Lee Yejin Y Hwang Jisun J Sung Jee-Young JY Jang Eun-Ju EJ Kim Yong-Nyun YN Yun Ji-Hye JH Han Jeongmin J Song Ji-Joon JJ Lee Weontae W Oh Eok-Soo ES
International journal of molecular sciences 20220524 11
We previously showed that a synthetic peptide (S2-P) corresponding to a portion of the human syndecan-2 (SDC2) sequence can bind to the pro-domain of matrix metalloproteinase-7 (MMP-7) to inhibit colon cancer activities. Since S2-P had a relatively weak binding affinity for the MMP-7 pro-domain, we herein modified the amino acid sequence of S2-P to improve the anticancer potential. On the basis of the interaction structure of S2-P and MMP-7, four peptides were generated by replacing amino acids ...[more]