Enhanced Extracellular Transfer of HLA-DQ Activates CD3⁺ Lymphocytes towards Compromised Treg Induction in Celiac Disease.

ABSTRACT: Celiac disease (CeD) manifests with autoimmune intestinal inflammation from gluten and genetic predisposition linked to human leukocyte antigen class-II (HLA-II) gene variants. Antigen-presenting cells facilitate gluten exposition through the interaction of their surface major histocompatibility complex (MHC) with the T cell receptor (TCR) on T lymphocytes. This fundamental mechanism of adaptive immunity has broadened upon recognition of extracellular exosomal MHC, raising awareness of an alternative means for antigen presentation. This study demonstrates that conditioned growth media (CGM) previously exposed to monocyte-derived dendritic cells from CeD significantly downregulates the CD3⁺ lineage marker of control T cells. Such increased activation was reflected in their elevat

SUBMITTER: Hudec M 

PROVIDER: S-EPMC9181181 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature