Ontology highlight
ABSTRACT:
SUBMITTER: Graves J
PROVIDER: S-EPMC9181506 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Graves John J Garbett Shawn S Zhou Zilu Z Schildcrout Jonathan S JS Peterson Josh J
Medical decision making : an international journal of the Society for Medical Decision Making 20210318 4
We discuss tradeoffs and errors associated with approaches to modeling health economic decisions. Through an application in pharmacogenomic (PGx) testing to guide drug selection for individuals with a genetic variant, we assessed model accuracy, optimal decisions, and computation time for an identical decision scenario modeled 4 ways: using 1) coupled-time differential equations (DEQ), 2) a cohort-based discrete-time state transition model (MARKOV), 3) an individual discrete-time state transitio ...[more]