Impact of Antihypertensive Drug Class on Outcomes in SPRINT.

ABSTRACT:

Background

The primary objective of this analysis is to assess if greater exposure to any major antihypertensive drug class was associated with reduced primary composite outcome events in SPRINT (Systolic Blood Pressure Intervention Trial).

Methods

This is a secondary analysis of the SPRINT trial evaluating whether longitudinal, time varying exposure to any major antihypertensive drug class had any impact on primary outcome events, after adjusting for effects of randomization arm, time varying achieved systolic blood pressure, other drug class exposure, and baseline characteristics.

Results

Nine thousand two hundred fifty-two participants were included. After adjustments, exposure of one year or greater to thiazide-type diuretics or renin-angiotensin system blockers w

SUBMITTER: DeCarolis DD 

PROVIDER: S-EPMC9181608 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature