Trace Oxygen Affects Osmium Redox Polymer Synthesis for Wired Enzymatic Biosensors.

ABSTRACT: Electrochemical sensors that utilize enzymes are a sensitive, inexpensive means of detecting biologically relevant analytes. These sensors are categorized based on their construction and method of signal transport. Type I sensors consist of a crosslinked enzyme on an electrode surface and are potentially subject to interference from byproducts and other biological analytes. However, type II sensors help alleviate this problem with the addition of a redox polymer layer that assists in signal transduction, thus minimizing interferences. An osmium-loaded poly(vinylimidazole) polymer (Os-PVI) is commonly used with successful results, and when combined with an enzyme yields a type II sensor. Our initial attempts at the synthesis of this polymer resulted in an unexpected osmium precursor, which

SUBMITTER: Calhoun MC 

PROVIDER: S-EPMC9183174 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature