Norepinephrine potentiates and serotonin depresses visual cortical responses by transforming eligibility traces.

ABSTRACT: Reinforcement allows organisms to learn which stimuli predict subsequent biological relevance. Hebbian mechanisms of synaptic plasticity are insufficient to account for reinforced learning because neuromodulators signaling biological relevance are delayed with respect to the neural activity associated with the stimulus. A theoretical solution is the concept of eligibility traces (eTraces), silent synaptic processes elicited by activity which upon arrival of a neuromodulator are converted into a lasting change in synaptic strength. Previously we demonstrated in visual cortical slices the Hebbian induction of eTraces and their conversion into LTP and LTD by the retroactive action of norepinephrine and serotonin Here we show in vivo in mouse V1 that the induction of eTraces and their conversi

SUBMITTER: Hong SZ 

PROVIDER: S-EPMC9184610 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature