Large-scale multi-omics analysis suggests specific roles for intragenic cohesin in transcriptional regulation.

ABSTRACT: Cohesin, an essential protein complex for chromosome segregation, regulates transcription through a variety of mechanisms. It is not a trivial task to assign diverse cohesin functions. Moreover, the context-specific roles of cohesin-mediated interactions, especially on intragenic regions, have not been thoroughly investigated. Here we perform a comprehensive characterization of cohesin binding sites in several human cell types. We integrate epigenomic, transcriptomic and chromatin interaction data to explore the context-specific functions of intragenic cohesin related to gene activation. We identify a specific subset of cohesin binding sites, decreased intragenic cohesin sites (DICs), which are negatively correlated with transcriptional regulation. A subgroup of DICs is enriched with enhan

SUBMITTER: Wang J 

PROVIDER: S-EPMC9184728 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature