Risk factors for overcorrection of severe hyponatremia: a post hoc analysis of the SALSA trial.

ABSTRACT:

Background

Hyponatremia overcorrection can result in irreversible neurologic impairment such as osmotic demyelination syndrome. Few prospective studies have identified patients undergoing hypertonic saline treatment with a high risk of hyponatremia overcorrection.

Methods

We conducted a post hoc analysis of a multicenter, prospective randomized controlled study, the SALSA trial, in 178 patients aged above 18 years with symptomatic hyponatremia (mean age, 73.1 years; mean serum sodium level, 118.2 mEq/L). Overcorrection was defined as an increase in serum sodium levels by >12 or 18 mEq/L within 24 or 48 hours, respectively.

Results

Among the 178 patients, 37 experienced hyponatremia overcorrection (20.8%), which was independently associated with initial serum sodium le

SUBMITTER: Yang H 

PROVIDER: S-EPMC9184842 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature