Risk factors for therapeutic failure in the management of post-operative peritonitis: a post hoc analysis of the DURAPOP trial.

ABSTRACT:

Background

Therapeutic failure is a frequent issue in the management of post-operative peritonitis.

Objectives

A post hoc analysis of the prospective, multicentre DURAPOP trial analysed the risk factors for failures in post-operative peritonitis following adequate source control and empirical antibiotic therapy in critically ill patients.

Patients and methods

Overall failures assessed post-operatively between Day 8 and Day 45 were defined as a composite of death and/or surgical and/or microbiological failures. Risk factors for failures were assessed using logistic regression analyses.

Results

Among the 236 analysed patients, overall failures were reported in 141 (59.7%) patients, including 30 (12.7%) deaths, 81 (34.3%) surgical and 95 (40.2%) microbiological fa

SUBMITTER: Montravers P 

PROVIDER: S-EPMC8598293 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature