Low total osteocalcin levels are associated with all-cause and cardiovascular mortality among patients with type 2 diabetes: a real-world study.

ABSTRACT:

Background

The association between osteocalcin and mortality has been scantly studied. We aimed to investigate the association between osteocalcin along with its trajectories and mortality based on long-term longitudinal data.

Methods

We performed a retrospective cohort study of 9413 type 2 diabetic patients with at least three measurements of total serum osteocalcin within 3 years since their first inpatient diagnosis of type 2 diabetes. Baseline, mean values of osteocalcin levels and their trajectories were used as exposures. A multivariable-adjusted Cox proportional hazards model was used to estimate the association of osteocalcin levels and their trajectories with mortality.

Results

During a mean follow-up of 5.37 years, 1638 patients died, of whom 588 were due to

SUBMITTER: Shen Y 

PROVIDER: S-EPMC9185881 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature