Prenatal exposure to multiple organochlorine compounds and childhood body mass index.

ABSTRACT:

Background

Prenatal exposure to organochlorine compounds (OCs) has been associated with increased childhood body mass index (BMI); however, only a few studies have focused on longitudinal BMI trajectories, and none of them used multiple exposure mixture approaches.

Aim

To determine the association between in-utero exposure to eight OCs and childhood BMI measures (BMI and BMI z-score) at 4 years and their yearly change across 4-12 years of age in 279 Rhea child-mother dyads.

Methods

We applied three approaches: (1) linear mixed-effect regressions (LMR) to associate individual compounds with BMI measures; (2) Bayesian weighted quantile sum regressions (BWQSR) to provide an overall OC mixture association with BMI measures; and (3)Bayesian varying coefficient kerne

SUBMITTER: Colicino E 

PROVIDER: S-EPMC9187184 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature