Factors associated with clinical progression to severe COVID-19 in people with cystic fibrosis: A global observational study.

ABSTRACT:

Background

This international study aimed to characterise the impact of acute SARS-CoV-2 infection in people with cystic fibrosis and investigate factors associated with severe outcomes. Methods Data from 22 countries prior to 13^th December 2020 and the introduction of vaccines were included. It was de-identified and included patient demographics, clinical characteristics, treatments, outcomes and sequalae following SARS-CoV-2 infection. Multivariable logistic regression was used to investigate factors associated with clinical progression to severe COVID-19, using the primary outcome of hospitalisation with supplemental oxygen.

Results

SARS-CoV-2 was reported in 1555 people with CF, 1452 were included in the analysis. One third were aged <18 years, and 9.4% were s

SUBMITTER: Carr SB 

PROVIDER: S-EPMC9189103 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature