Pepsin A in Tracheal Secretions From Patients Receiving Mechanical Ventilation.

ABSTRACT:

Background

In patients in the intensive care unit (ICU) receiving mechanical ventilation, aspiration of gastric contents may lead to ventilator-associated events and other adverse outcomes. Pepsin in pulmonary secretions is a biomarker of microaspiration of gastric contents.

Objectives

To evaluate the association between tracheal pepsin A and clinical outcomes related to ventilator use.

Methods

A subset of 297 patients from a larger clinical trial on aspiration of oral secretions in adults receiving mechanical ventilation consented to have pepsin A measured in their tracheal aspirate samples. A concentration ≥6.25 ng/mL indicated a positive result. Abundant microaspiration was defined as pepsin A in ≥30% of samples. Statistical analyses included analysis of variance,

SUBMITTER: Talbert S 

PROVIDER: S-EPMC9189863 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature