Ductular Reaction Cells Display an Inflammatory Profile and Recruit Neutrophils in Alcoholic Hepatitis.

ABSTRACT: Chronic liver diseases are characterized by the expansion of ductular reaction (DR) cells and the expression of liver progenitor cell (LPC) markers. In alcoholic hepatitis (AH), the degree of DR expansion correlates with disease progression and short-term survival. However, little is known about the biological properties of DR cells, their impact on the pathogenesis of human liver disease, and their contribution to tissue repair. In this study, we have evaluated the transcriptomic profile of DR cells by laser capture microdissection in patients with AH and assessed its association with disease progression. The transcriptome analysis of cytokeratin 7-positive (KRT7⁺ ) DR cells uncovered intrinsic gene pathways expressed in DR and genes associated with alcoholic liver disease prog

SUBMITTER: Aguilar-Bravo B 

PROVIDER: S-EPMC9189898 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature