Ontology highlight
ABSTRACT:
SUBMITTER: Dilworth D
PROVIDER: S-EPMC9189931 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Dilworth David D Hanley Ronan P RP Ferreira de Freitas Renato R Allali-Hassani Abdellah A Zhou Mengqi M Mehta Naimee N Marunde Matthew R MR Ackloo Suzanne S Carvalho Machado Raquel Arminda RA Khalili Yazdi Aliakbar A Owens Dominic D G DDG Vu Victoria V Nie David Y DY Alqazzaz Mona M Marcon Edyta E Li Fengling F Chau Irene I Bolotokova Albina A Qin Su S Lei Ming M Liu Yanli Y Szewczyk Magdalena M MM Dong Aiping A Kazemzadeh Sina S Abramyan Tigran T Popova Irina K IK Hall Nathan W NW Meiners Matthew J MJ Cheek Marcus A MA Gibson Elisa E Kireev Dmitri D Greenblatt Jack F JF Keogh Michael-C MC Min Jinrong J Brown Peter J PJ Vedadi Masoud M Arrowsmith Cheryl H CH Barsyte-Lovejoy Dalia D James Lindsey I LI Schapira Matthieu M
Nature chemical biology 20211115 1
Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with active gene transcription and intergenic DNA methylation. In addition to a methyltransferase domain, NSD2 harbors two proline-tryptophan-tryptophan-proline (PWWP) domains and five plant homeodomains (PHDs) believed to serve as chromatin reading modules. Here, we report a chemical probe targeting the N-terminal PWWP (PWWP1) domai ...[more]