Plasma neurofilament light and its association with all-cause mortality risk among urban middle-aged men and women.

ABSTRACT:

Background

Neurofilament light chain (NfL) is released into the blood during neuronal damage. NfL is linked to mortality in neurological disorders, remaining unexplored in population studies. We investigated whether initial (v₁) and annualized change (δ) in plasma NfL can predict all-cause mortality in middle-aged dementia-free urban adults.

Methods

Longitudinal data were from 694 participants in the Healthy Aging in Neighborhoods of Diversity Across the Life Span study (HANDLS, mean age_v1: 47.8 years, 42% male, 55.8% African American). Plasma NfL was measured prospectively at three visits. Analyses included Cox proportional hazards models for all-cause mortality risk and 4-way decomposition testing for interaction and mediation.

Results

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SUBMITTER: Beydoun MA 

PROVIDER: S-EPMC9190073 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature