Dataset Information

Characteristics of Anterior Segment in Congenital Ectopia Lentis: An SS-OCT Study.

ABSTRACT:

Purpose

To investigate the characteristics of anterior chamber angle parameters in congenital ectopia lentis (CEL) patients and to evaluate the sensitivity and specificity of anterior segment parameters in distinguishing CEL from healthy controls. Setting. Zhongshan Ophthalmic Center, Guangzhou, China.

Design

Cross-sectional study.

Methods

35 CEL patients and 35 age- and sex-matched healthy controls were recruited. Axial length (AL) and anterior segment parameters including anterior chamber width (ACW), angle open distance (AOD), angle recess area (ARA), trabecular-iris space area (TISA), and trabecular-iris angle (TIA) were measured. All the above parameters and the ratio index of angle parameters, which was defined as the angle parameter value of the narrower side to that of the contralateral side, were compared between CEL and controls. Receiver operating characteristic (ROC) curves were also plotted to evaluate the diagnostic performance of anterior chamber angle parameters in CEL patients.

Results

All angle parameters of the contralateral side to the dislocated lens side were significantly smaller than those of the dislocated lens side in CEL (all P < 0.05). For the diagnostic performance of anterior chamber angle parameters, the ratio index of TIAr500 combined with TIAr750 had the best diagnostic performance for CEL screening (AUC = 0.798), and TIAr500 of 0.887 and TIAr750 of 0.917 were detected to be the optimal cut-off points, representing a sensitivity of 89.8% and specificity of 68.7%.

Conclusion

The contralateral side to the dislocated lens side in the CEL had a narrower anterior chamber angle. TIAr500 combined with TIAr750 is the optimal combination strategy for ectopia lentis screening.

SUBMITTER: Qi H

PROVIDER: S-EPMC9192328 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Characteristics of Anterior Segment in Congenital Ectopia Lentis: An SS-OCT Study.

Qi Haotian H Jin Guangming G Zou Minjie M Young Charlotte C Liu Liyan L Lian Zhangkai Z Guo Dongwei D Liu Zhenzhen Z Zheng Danying D

Journal of ophthalmology 20220606

<h4>Purpose</h4>To investigate the characteristics of anterior chamber angle parameters in congenital ectopia lentis (CEL) patients and to evaluate the sensitivity and specificity of anterior segment parameters in distinguishing CEL from healthy controls. <i>Setting</i>. Zhongshan Ophthalmic Center, Guangzhou, China.<h4>Design</h4>Cross-sectional study.<h4>Methods</h4>35 CEL patients and 35 age- and sex-matched healthy controls were recruited. Axial length (AL) and anterior segment parameters in ...[more]

PMID: 35706501

Similar Datasets

Project description:PurposeTo explore early changes in circumferential anterior segment structures following Implantable Collamer Lens (ICL) V4c implantation via swept-source optical coherence tomography (SS-OCT).MethodsIn 103 eyes of 56 myopic patients undergoing ICL V4c surgery, anterior segments were measured via SS-OCT to compute local anterior chamber angle (ACA) parameters on the nasal-temporal (0°-180°), superior-inferior (90°-270°), and superior nasal-inferior temporal (80°-260°) meridians, including angle-opening distance at 500 µm (AOD500), trabecular-iris space area at 500 µm (TISA500), trabecular-iris angle at 500 µm (TIA500), and circumferential ACA parameters, including AOD area at 500 µm (AODA500), trabecular-iris circumference volume at 500 µm (TICV500), and the index and area of iris-trabecular contact (ITC). ACA parameters were compared preoperatively and at 1 week, 1 month, and 3 months postoperatively and compared among quadrants. Mixed-effects model was used to evaluate the parameters correlated with the post-ITC parameters.ResultsThe mean AOD500, TISA500, TIA500, AODA500, and TICV500 were decreased by 65.4% to 71%, 64.1% to 69.3%, 53.8% to 61.5%, 69.9%, and 69.2%, respectively, at 1 week postoperatively. The ITC index and area values rose from 1.436% ± 4.427% and 0.070 ± 0.254 mm2 to 12.343% ± 13.216% and 0.903 ± 1.304 mm2 (all P < 0.05). No further decreases in ACA parameters were observed beyond 1 week postoperatively (all P > 0.05). Significant differences were observed among quadrants, with the narrowest in the superior-nasal quadrant, followed by the superior quadrant. The 3-month vault was significantly correlated with the ITC index and area at 3 months postoperatively.ConclusionsAnterior segment structures were significantly shallow at 1 week with no further decreases thereafter. In light of anatomical variability, we recommend circumferential meridian scan to assess angle status, with special attention to the superior-nasal and superior quadrants.Translational relevanceWe investigated the early changes in circumferential anterior segment structures following ICL V4c implantation, thus providing a better perspective for understanding anterior segment structural characteristics after ICL V4c surgery.

Dataset Information

Characteristics of Anterior Segment in Congenital Ectopia Lentis: An SS-OCT Study.

Purpose

Design

Methods

Results

Conclusion

Publications

Characteristics of Anterior Segment in Congenital Ectopia Lentis: An SS-OCT Study.

Similar Datasets

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