Identification of Immune-Related lncRNA Regulatory Network in Pulpitis.

ABSTRACT:

Background

Long noncoding RNAs (lncRNAs) are emerging as critical regulators of various biological processes, including immune regulation.

Methods

Due to the critical significance of immunological responses in the development and progression of pulpitis, we used an integrated algorithm to identify immune-related lncRNAs and then examined the lncRNA-immunity regulation network in pulpitis. Before identifying immune-related lncRNAs, the data from GEO datasets were precleaned. ConsensusClusterPlus was used to differentiate immune-related pulpitis subgroups. Enrichment analysis using GO and MSigDB databases was employed to determine the differences in molecular function, cellular component, and biological process between the two pulpitis subtypes.

Results

An integrated al

SUBMITTER: Du J 

PROVIDER: S-EPMC9194960 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature