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Early Clinical and Electrophysiological Brain Dysfunction Is Associated With ICU Outcomes in COVID-19 Critically Ill Patients With Acute Respiratory Distress Syndrome: A Prospective Bicentric Observational Study.


ABSTRACT: Describe the prevalence of acute cerebral dysfunction and assess the prognostic value of an early clinical and electroencephalography (EEG) assessment in ICU COVID-19 patients. Prospective observational study. Two tertiary critical care units in Paris, France, between April and December 2020. Adult critically ill patients with COVID-19 acute respiratory distress syndrome. Neurologic examination and EEG at two time points during the ICU stay, first under sedation and second 4-7 days after sedation discontinuation. Association of EEG abnormalities (background reactivity, continuity, dominant frequency, and presence of paroxystic discharges) with day-28 mortality and neurologic outcomes (coma and delirium recovery). Fifty-two patients were included, mostly male (81%), median (interquartile range) age 68 years (56-74 yr). Delayed awakening was present in 68% of patients (median awakening time of 5 d [2-16 d]) and delirium in 74% of patients who awoke from coma (62% of mixed delirium, median duration of 5 d [3-8 d]). First, EEG background was slowed in the theta-delta range in 48 (93%) patients, discontinuous in 25 patients (48%), and nonreactive in 17 patients (33%). Bifrontal slow waves were observed in 17 patients (33%). Early nonreactive EEG was associated with lower day-28 ventilator-free days (0 vs 16; p = 0.025), coma-free days (6 vs 22; p = 0.006), delirium-free days (0 vs 17; p = 0.006), and higher mortality (41% vs 11%; p = 0.027), whereas discontinuous background was associated with lower ventilator-free days (0 vs 17; p = 0.010), coma-free days (1 vs 22; p < 0.001), delirium-free days (0 vs 17; p = 0.001), and higher mortality (40% vs 4%; p = 0.001), independently of sedation and analgesia. Clinical and neurophysiologic cerebral dysfunction is frequent in COVID-19 ARDS patients. Early severe EEG abnormalities with nonreactive and/or discontinuous background activity are associated with delayed awakening, delirium, and day-28 mortality.

SUBMITTER: Benghanem S 

PROVIDER: S-EPMC9196923 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature

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Early Clinical and Electrophysiological Brain Dysfunction Is Associated With ICU Outcomes in COVID-19 Critically Ill Patients With Acute Respiratory Distress Syndrome: A Prospective Bicentric Observational Study.

Benghanem Sarah S   Cariou Alain A   Diehl Jean-Luc JL   Marchi Angela A   Charpentier Julien J   Augy Jean-Loup JL   Hauw-Berlemont Caroline C   Gavaret Martine M   Pène Frédéric F   Mira Jean-Paul JP   Sharshar Tarek T   Hermann Bertrand B  

Critical care medicine 20220209 7


<h4>Objectives</h4>Describe the prevalence of acute cerebral dysfunction and assess the prognostic value of an early clinical and electroencephalography (EEG) assessment in ICU COVID-19 patients.<h4>Design</h4>Prospective observational study.<h4>Setting</h4>Two tertiary critical care units in Paris, France, between April and December 2020.<h4>Patients</h4>Adult critically ill patients with COVID-19 acute respiratory distress syndrome.<h4>Interventions</h4>Neurologic examination and EEG at two ti  ...[more]

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