Early Clinical and Electrophysiological Brain Dysfunction Is Associated With ICU Outcomes in COVID-19 Critically Ill Patients With Acute Respiratory Distress Syndrome: A Prospective Bicentric Observational Study.

ABSTRACT:

Objectives

Describe the prevalence of acute cerebral dysfunction and assess the prognostic value of an early clinical and electroencephalography (EEG) assessment in ICU COVID-19 patients.

Design

Prospective observational study.

Setting

Two tertiary critical care units in Paris, France, between April and December 2020.

Patients

Adult critically ill patients with COVID-19 acute respiratory distress syndrome.

Interventions

Neurologic examination and EEG at two time points during the ICU stay, first under sedation and second 4-7 days after sedation discontinuation.

Measurements and main results

Association of EEG abnormalities (background reactivity, continuity, dominant frequency, and presence of paroxystic discharges) with day-28 mortality and neuro

SUBMITTER: Benghanem S 

PROVIDER: S-EPMC9196923 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature