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NK Cells, Monocytes and Macrophages in HIV-1 Control: Impact of Innate Immune Responses.

ABSTRACT: Rapid and synchronized responses of innate immune cells are an integral part of managing viral spread in acute virus infections. In human immunodeficiency virus type 1 (HIV-1) infection, increased immune control has been associated with the expression of certain natural killer (NK) cell receptors. Further, immune activation of monocytes/macrophages and the presence of specific cytokines was linked to low levels of HIV-1 replication. In addition to the intrinsic antiviral capabilities of NK cells and monocytes/macrophages, interaction between these cell types has been shown to substantially enhance NK cell function in the context of viral infections. This review discusses the involvement of NK cells and monocytes/macrophages in the effective control of HIV-1 and highlights aspects of innate immune crosstalk in viral infections that may be of relevance to HIV-1 infection.

SUBMITTER: Mensching L

PROVIDER: S-EPMC9197227 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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NK Cells, Monocytes and Macrophages in HIV-1 Control: Impact of Innate Immune Responses.

Mensching Leonore L Hoelzemer Angelique A

Frontiers in immunology 20220527

Rapid and synchronized responses of innate immune cells are an integral part of managing viral spread in acute virus infections. In human immunodeficiency virus type 1 (HIV-1) infection, increased immune control has been associated with the expression of certain natural killer (NK) cell receptors. Further, immune activation of monocytes/macrophages and the presence of specific cytokines was linked to low levels of HIV-1 replication. In addition to the intrinsic antiviral capabilities of NK cells ...[more]

PMID: 35711433

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Dataset Information

NK Cells, Monocytes and Macrophages in HIV-1 Control: Impact of Innate Immune Responses.

Publications

NK Cells, Monocytes and Macrophages in HIV-1 Control: Impact of Innate Immune Responses.

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