Reducing ER stress with chaperone therapy reverses sleep fragmentation and cognitive decline in aged mice.

ABSTRACT: As the aging population grows, the need to understand age-related changes in health is vital. Two prominent behavioral changes that occur with age are disrupted sleep and impaired cognition. Sleep disruptions lead to perturbations in proteostasis and endoplasmic reticulum (ER) stress in mice. Further, consolidated sleep and protein synthesis are necessary for memory formation. With age, the molecular mechanisms that relieve cellular stress and ensure proper protein folding become less efficient. It is unclear if a causal relationship links proteostasis, sleep quality, and cognition in aging. Here, we used a mouse model of aging to determine if supplementing chaperone levels reduces ER stress and improves sleep quality and memory. We administered the chemical chaperone 4-phenyl butyrate (PB

SUBMITTER: Hafycz JM 

PROVIDER: S-EPMC9197403 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature