Evaluation of the relationship between polymorphisms in CYP2C19 and the single-dose pharmacokinetics of omeprazole in healthy Chinese volunteers: A multicenter study.

ABSTRACT: The aim of this study was to evaluate the relationship between polymorphisms in CYP2C19 and the single-dose pharmacokinetics (PKs) of omeprazole in healthy Chinese volunteers. A 20 mg single dose of omeprazole (Losec) enteric-coated capsules or tablets was orally administered to 656 healthy subjects from eight subcenters. The polymorphic alleles of CYP2C19*2, *3, and *17 were determined by Sanger sequencing and Agena mass array. Plasma concentrations of omeprazole were determined by high-performance liquid-chromatography tandem mass spectrometry. PK parameters of area under the concentration versus time curve (AUC)_0-t , AUC from zero to infinity (AUC_0-∞ ), maximum plasma concentration (C_max ), and terminal half-life (t_1/2 ) were significantly inf

SUBMITTER: Zhou S 

PROVIDER: S-EPMC9199891 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature