Ontology highlight
ABSTRACT:
SUBMITTER: Adhikari D
PROVIDER: S-EPMC9200162 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Science advances 20220615 24
Eggs contain about 200,000 mitochondria that generate adenosine triphosphate and metabolites essential for oocyte development. Mitochondria also integrate metabolism and transcription via metabolites that regulate epigenetic modifiers, but there is no direct evidence linking oocyte mitochondrial function to the maternal epigenome and subsequent embryo development. Here, we have disrupted oocyte mitochondrial function via deletion of the mitochondrial fission factor Drp1. Fission-deficient oocyte ...[more]