SETD4-mediated KU70 methylation suppresses apoptosis.
Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC9201767 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Publications
SETD4-mediated KU70 methylation suppresses apoptosis.
Wang Yuan Y Liu Bochao B Lu Huimei H Liu Jingmei J Romanienko Peter J PJ Montelione Gaetano T GT Shen Zhiyuan Z
Cell reports 20220501 6
The mammalian KU70 is a pleiotropic protein functioning in DNA repair and cytoplasmic suppression of apoptosis. We report a regulatory mechanism by which KU70's cytoplasmic function is enabled due to a methylation at K570 of KU70 by SET-domain-containing protein 4 (SETD4). While SETD4 silencing reduces the level of methylated KU70, over-expression of SETD4 enhances methylation of KU70. Mutations of Y272 and Y284 of SETD4 abrogate methylation of KU70. Although SETD4 is predominantly a nuclear pro ...[more]
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