Dataset Information

Cannabis use and subjective response to alcohol in the human laboratory.

ABSTRACT:

Background

Cannabis is often used in combination with alcohol; yet, whether cannabis use impacts risk factors for alcohol use disorder (AUD) remains unknown. Subjective response (SR) to alcohol represents a biobehavioral risk factor for subsequent heavy drinking and for developing AUD. Given the high prevalence of alcohol and cannabis co-use, it is plausible to hypothesize that cannabis users differ in SR to alcohol compared to non-cannabis users. The purpose of this study is to examine the influence of past-month cannabis use on subjective response to alcohol in the human laboratory.

Methods

This study culled data from multiple alcohol administration trials to test whether cannabis users, compared to non-cannabis users, differed in subjective response to alcohol, comprised of four domains: stimulation, sedation, negative affect, and craving. Non-treatment-seeking heavy drinkers (N = 168) completed a battery of self-report scales of mood and alcohol/cigarette/cannabis use and problems. All participants completed an intravenous alcohol administration session wherein SR domains were measured at the following breath alcohol concentrations (BrAC): baseline (i.e., 0), 20, 40, and 60 mg%.

Results

Multilevel statistical analyses revealed that cannabis users had a greater reduction in negative affect during alcohol administration, compared to non-cannabis users. No significant differences were found for the other SR domains.

Conclusions

Using a large sample and advanced data analytic methods, this study extends the literature by suggesting that cannabis users are more sensitive to alcohol-induced reductions in negative affect compared to non-cannabis users. This work extends research on how cannabis use may influence risk factors for AUD, such as subjective response to alcohol.

SUBMITTER: Nieto SJ

PROVIDER: S-EPMC9203930 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Publications

Cannabis use and subjective response to alcohol in the human laboratory.

Nieto Steven J SJ Venegas Alexandra A Hudson Jazzlyne J Ray Lara A LA

Drug and alcohol dependence 20220430

<h4>Background</h4>Cannabis is often used in combination with alcohol; yet, whether cannabis use impacts risk factors for alcohol use disorder (AUD) remains unknown. Subjective response (SR) to alcohol represents a biobehavioral risk factor for subsequent heavy drinking and for developing AUD. Given the high prevalence of alcohol and cannabis co-use, it is plausible to hypothesize that cannabis users differ in SR to alcohol compared to non-cannabis users. The purpose of this study is to examine ...[more]

PMID: 35523112

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Dataset Information

Cannabis use and subjective response to alcohol in the human laboratory.

Background

Methods

Results

Conclusions

Publications

Cannabis use and subjective response to alcohol in the human laboratory.

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