CCL5-Secreting Virtual Memory CD8+ T Cells Inversely Associate With Viral Reservoir Size in HIV-1-Infected Individuals on Antiretroviral Therapy.

ABSTRACT: Recent studies highlighted that CD8+ T cells are necessary for restraining reservoir in HIV-1-infected individuals who undergo antiretroviral therapy (ART), whereas the underlying cellular and molecular mechanisms remain largely unknown. Here, we enrolled 60 virologically suppressed HIV-1-infected individuals, to assess the correlations of the effector molecules and phenotypic subsets of CD8+ T cells with HIV-1 DNA and cell-associated unspliced RNA (CA usRNA). We found that the levels of HIV-1 DNA and usRNA correlated positively with the percentage of CCL4+CCL5- CD8+ central memory cells (T_CM) while negatively with CCL4-CCL5+ CD8+ terminally differentiated effector memory cells (T_EMRA). Moreover, a virtual memory CD8+ T cell (T_VM) subset was enriched in CCL

SUBMITTER: Hu W 

PROVIDER: S-EPMC9204588 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature